Key results
The company
Prima Mente
primamente.comBiological foundation models for neurological research and brain health.
Result highlights
- 91% match to methylation patterns
- 83% accuracy generating DNA fragments
- Up to 20x DNA concentration increase
- 10x expansion of usable cfDNA information
- 0.89 accuracy for early disease detection
The story
An AI biology startup based in London and San Francisco aims to cure severe neurological conditions by understanding the brain across health, age, and disease.
Neurological diseases like Alzheimer's develop gradually with subtle symptoms, making early detection difficult when relying solely on traditional DNA analysis. Critical epigenetic signals like methylation are often invisible to DNA-only approaches, preventing a complete understanding of disease progression.
The company is piloting its Pleiades foundation model in a live clinical study across 15 UK sites to classify patients with suspected neurodegenerative conditions. This autoregressive transformer decoder was trained on 1.9 trillion tokens of epigenetic data using 256 NVIDIA H200 GPUs on the DGX Cloud Lepton AI platform. The system analyzes both genomic data and chemical modifications to identify disease signals invisible to standard DNA models.
Quotes
“Diagnostic and prognostic care will rapidly improve with the use of AI in clinical practice, and, with Prima Mente, I hope SANDBOX is just the start.”
Implementation partner
Nebius
nebius.comProvided Prima Mente with NVIDIA supercomputing clusters and technical support for model training.